The Britain-based Syrian Observatory for Human Rights, a Syria war monitor, said seven people were killed and ten of others were injured in a car-bomb explosion near the industrial area in the south of Ras al-Ain city.
SANA said the blast went off at the southern entrance to the city of Ras al-Ain.
No further details were immediately available.
Turkish troops and allied Syrian fighters captured the area last October when Ankara invaded northeastern Syria to drive away Syrian Kurdish fighters from the shared border.
Ankara views the Kurdish fighters as terrorists for their links to a Kurdish insurgency inside Turkey. The fighters had however partnered with the US against the ISIS group.
Nearly half a million people have been killed in Syria’s nine-year war which began as a popular uprising against the rule of Syrian President Bashar Assad and turned into an armed insurgency following a brutal crackdown.